0. setup

Install ananconda to be the easiest, then

pip install wfastcgi
pip install django

1. create the sherlock project

django-admin startproject sherlock

2. unlock the handlers

%windir%\system32\inetsrv\appcmd unlock config -section:system.webServer/handlers

3. set the physical path

%windir%\system32\inetsrv\appcmd set vdir "Default Web Site/" -physicalPath:"e:\www\sherlock"

4. create the views.py

from django.http import HttpResponse
def home(request):
    html = "<html><body>Elementary!</body></html>"
    return HttpResponse(html)

5. update urls.py

from django.conf.urls import url
import sherlock.views

urlpatterns = [
    url(r'^$', sherlock.views.home),

6. update web.config

create one if not existed yet

   <add key="WSGI_HANDLER" value="django.core.wsgi.get_wsgi_application()" />
   <add key="PYTHONPATH" value="e:\www\sherlock" />
   <add key="DJANGO_SETTINGS_MODULE" value="sherlock.settings" />
       <add name="Python FastCGI" path="*" verb="*" modules="FastCgiModule" scriptProcessor="e:\anaconda3\python.exe|e:\anaconda3\Lib\site-packages\wfastcgi.py" resourceType="Unspecified" />

Last but not least

Mind the permission settings of the www folder and also the django package folder, ensure IIS_IUSER has both read and execute access.